Oxidatively degradable poly(thioketal urethane)/ceramic composite bone cements with bone-like strength

Injectable Degradable Composite Materials for Bone Repair and Drug Delivery

OsteoInk: Bioactive Bone Cements

Fiber reinforced calcium phosphate cements -- on the way to degradable load bearing bone substitutes?

Calcium phosphate cements (CPC) are well-established materials for the repair of bone defects with excellent biocompatibility and bioactivity. However, brittleness and low flexural/tensile strength so far restrict their application to non-load bearing areas. Reinforcement of CPC with fibers can substantially improve its strength and toughness and has been one major strategy to overcome the pres...

Resorbable nanocomposites with bone-like strength and enhanced cellular activity

Bone cements for treatment of fractures at weight-bearing sites are subjected to dynamic physiological loading from daily activities. An ideal bone cement rapidly sets after injection, exhibits bone-like strength, stimulates osteogenic differentiation of endogenous cells, and resorbs at a rate aligned with patient biology. However, currently available materials fall short of these targeted prop...

Fatigue performance of a high-strength, degradable calcium phosphate bone cement.

Calcium phosphate cements (CPCs) are clinically used as injectable materials to fill bone voids and to improve hardware fixation in fracture surgery. In vivo they are dynamically loaded; nonetheless little is known about their fatigue properties. The aim of this study was to, for the first time, investigate the fatigue performance of a high-strength, degradable (brushitic) CPC, and also evaluat...